You don’t have to travel far on Route 66 in Missouri to realize you’re in for one fantastic road trip. Route 66 includes two of Missouri’s largest cities, notable attractions, scenic views and motor courts harkening to a bygone era. Home to more than 280 miles of the “Mother Road,” we recommend taking the “scenic route” and spending a few days to cover Missouri’s section of Route 66.
Click here to download Missouri Life's Guide to Missouri's Route 66.
Begin your journey from St. Louis, one of the most popular cities on Route 66. (Please note, some of the sites of interest listed below cannot accommodate motorcoach groups but would complement a driving tour.)